The CG15445 gene is the Drosophila homolog of NUB1, which has been referred to as Drosophila NUB1 following the study by Lu and colleagues in which a Drosophila model of HD was employed to identify gene modifiers of the toxicity associated with high levels of the mutant form of the protein huntingtin (mHTT) [77]. This evidence concerns the gene HTT and Huntington disease.