Interestingly, this lack of TGFβ signalling in CD4+ T-cells did not affect the classical Th2, Th9 nor Th1 immune cytokine responses during the time-course of infection, with no significant difference observed in parasite specific IL-13, 4, 9 (Fig 2B) and IFNγ (S2A Fig) production from mLN antigen restimulation. This evidence concerns the gene NELFCD and infection.