Interestingly, p120 deletion in murine esophagus and epidermis results in inflammation, hyperproliferation, and squamous cell cancer that appear to be mediated by aberrant activation of RHOA upstream of NFκB [36, 38, 66], and Rho GTPases also function in immune cell migration and the tumor microenvironment [67, 68]. This evidence concerns the gene RHOA and squamous cell carcinoma.