In particular, the NFκB signaling pathway has emerged as a critical activator of epithelial inflammation and inflammation-mediated carcinogenesis [11, 12], and in the esophagus, activated NFκB signaling is implicated in the development of ESCC and EoE, among other disorders [7, 13–20]. The gene discussed is NFKB1; the disease is esophageal squamous cell carcinoma.