Therefore especially in male AML patients with breast cancer in the family one should be careful to consider germline BRCA mutations as BRCA1 and BRCA2 mutations predispose to an increased risk for a broad spectrum of cancers, especially stomach, pancreas, prostate and colon cancer, but can also be associated with a higher occurrence of leukemia [8]. This evidence concerns the gene BRCA1 and colonic neoplasm.