This might due to the fact that patients with systemic allergic diseases like asthma, bronchitis, eczema and hay fever have similar immunopathology with VKC[6] which carried out by adhering of IgE molecules on the surfaces of mast cells which in turn release inflammation mediators like prostaglandins in the conjunctiva that probably lead to VKC[1,5]. The gene discussed is IGHE; the disease is allergic disease.