TRPM2 and carcinoma: Another reason for the downregulation of the TRPM2 mRNA expressions in our grade 2 EC and EH with atypia groups and the upregulation in grade 3 EC compared to EH without atypia may be the fact that, as mentioned above, estrogen is different in its effects on the endometrium at different periods and many factors coexist in vivo in the etiopathogenesis of carcinoma.