IFNG and non-small cell lung carcinoma: The activation of NK cells by cytokines such as type I interferons, IL‐12, and IL‐18 releases cytolytic granules for targeted cell disruption and cytokines for further immune response.72 NK cells primarily release IFN‐α, Th2‐associated cytokines, such as IL‐5 and IL‐13, and the regulatory IL‐10 cytokine may be released.73 Studies have shown that NSCLC cells release such soluble factors which inhibit the expression of granzyme B and IFN‐γ in intratumoral NK cells.