VEGFA and neoplasm: It has been found that tumor‐infiltrating NK cells show proangiogenic activity, with production of VEGF, placental growth factor, and IL‐8/CXCL8.74, 75 The high frequency of Treg and low frequency of NK cells have been observed in the malignant areas with vice versa situation in nonmalignant areas demonstrating strong cytolytic activity ex vivo.76, 77, 78 Their role in both adaptive and innate immunity makes NK cells an attractive target for therapeutic development.