Proinflammatory cytokines secreted by Th1 cells have a detrimental effect on tumor leading to tumor rejection and antitumor progression.46 Pancreatic β‐cell cancer mouse model has been used to demonstrate the role of these cytokines on tumor, wherein the group has shown the combined effect of interferon‐γ (IFN‐γ) and TNF mediated through arrest of STAT1 and TNFR1 signaling along with p16INK4a leading to senescence of Tag‐expressing cancers. This evidence concerns the gene TNFRSF1A and neoplasm.