Currently, legume lectins are the most extensively studied, including lectins from seeds of plants belonging to the Fabaceae family.28Dolichos lablab lectin (DLL) has been shown to weaken proangiogenic signals, specifically nuclear factor kappa B (NF-κB), matrix metalloproteinase (MMP-2 and 9) and vascular endothelial growth factor (VEGF) in lectin-exposed mice.29Lens culinaris agglutinin and Pisum sativum agglutinin are capable of disrupting HIV infection by preventing the interaction of viral surface glycoprotein gp120 with the cellular CD4 receptor.28 This evidence concerns the gene VEGFA and HIV infectious disease.