Overexpression of EGFR is frequently occurred in 30% to 98% of epithelial ovarian cancer; apart from that, intracellular EGFR dimerization could activate signaling pathways including the PI3K/Akt signaling pathway which functions as a regulatory role in tumor migration and invasion, cellular functions, as well as resistance to cell apoptosis in epithelial ovarian cancer [31]. This evidence concerns the gene AKT1 and neoplasm.