We found increased Il-1b mRNA level in hypothalamic blocks of control, C57BL/6 mice in response to insulin-induced hypoglycemia [F (1, 8) = 21.60, p < 0.01; Bonferroni’s post hoc test, t(8) = 4.93, p < 0.001]. The gene discussed is IL1B; the disease is Hypoglycemia.