The screened variants were classified as follows: 41 – pathogenic variants [classified according to the alteration in the CFTR gene as (I) n = 23 (56.09%), (II) n = 6 (14.63%), (III) n = 1 (2.43%), (IV) n = 6 (14.63%), (IV and V) n = 1 (2.43%) and (VI) n = 4 (9.75%)]; 14 – variants of uncertain significance, considering the findings of the literature and of this study [n = 9 – pathogenic among all predictors (characteristic that gives the high pathogenic potential and association with the diagnosis of CF); n = 5 – discordant among all predictors used]; and seven novel variants. The gene discussed is CFTR; the disease is cystic fibrosis.