To further understand the role of macrophage MVP in atherosclerosis, we generated myeloid-specific MVP deficiency and ApoE knockout mice (MVPMacKOApoEKO, MVPflox/floxApoEKOLyz2-Cre) and the littermates (MVPMacWTApoEKO, MVPflox/floxApoEKO) by crossing MVPflox/flox mice with Lyz2-Cre mice and ApoEKO mice. Here, APOE is linked to atherosclerosis.