In this study, Ang II-infused mice exhibited hypertension, cardiac hypertrophy, increases in BUN and serum creatinine, moderate albuminuria and renal pathological changes such as mild urinary cast, interstitial macrophage infiltration and modest interstitial fibrosis, along with an increase in renal fibrosis- and inflammation-related gene expression. The gene discussed is AGT; the disease is cardiac hypertrophy.