These data indicate that ITGA2 antibody-directed liposomes are over 4-times more effective in ablating GBM cells compared with non-specific IgG-Dox-LP, without affecting normal glial cells, suggesting that ITGA2-Dox-LP may be more selective and effective in treating GBM cells than the conventional non-targeting nanomedicines. Here, ITGA2 is linked to glioblastoma.