It has been known that human GBM cells secrete a variety of pro-angiogenic factors (e.g., vascular endothelial growth factor, VEGF)32, which may disrupt the integrity of human brain microvascular endothelial cell (HBMVEC) barriers, leading to an increased transendothelial delivery of ITGA2-Dox-LP. The gene discussed is ITGA2; the disease is glioblastoma.