MYH14 and eosinophilic esophagitis: Although a simplification of the underlying processes, our results point to 2 distinct additive mechanisms with the potential to account for increased stiffness in the EoE esophagus – (1) altered smooth muscle stiffness due to altered actin-myosin (revealed by responses to carbachol and histamine) and (2) altered extracellular matrix stiffness (revealed by loss of smooth muscle-mediated elastic recoil with strain).