CDH1 and eosinophilic esophagitis: Treatment with an EoE-like Th2 cytokine cocktail induced disease-relevant gene transcription, alterations in E-cadherin organization of the epithelial barrier as occurs in vivo in the active EoE disease state28, and also increased mucosal stiffness leading to compliance properties similar to those obtained from EoE patients during endoFLIP36.