PLN and eosinophilic esophagitis: TGFβ1 treatment of LSM bundles also significantly induced fibronectin and phospholamban expression from 1 to 3 weeks in culture (p < 0.001) (Fig. 4c).Histologically, collagen I was induced in full thickness ex vivo mucosa after 14 days of treatment with the EoE-like cytokine cocktail as compared with vehicle (Fig. 4d).