BRCA1 and cancer: To compare super-enhancer landscapes in BRCA1+/+ and BRCA1mut/+ normal human breast epithelia, primary HMECs were isolated from fresh cancer-free breast tissues of BRCA1 mutation carriers (BRCA1mut/+, n = 3) and non-carriers (BRCA1+/+, n = 3), who underwent prophylactic mastectomy and reduction mammoplasty, respectively.