With regard to KIR gene frequency in relation to TOAST subtype, we observed a higher frequency in subjects with LAAS subtype in comparison with subjects with other TOAST subtypes of 2DL3, 2DL4, 3DL2, 3DL3, and 3DP1*003 KIR genes, whereas with regard to interaction KIR-HLA, we observed a higher frequency of 2DL1HLAC1 in subjects with cardioembolic stroke subtype. Here, KIR3DL1 is linked to cardioembolic stroke.