HLA-B and ischemic stroke: Multiple logistic regression analysis considering variables predictive of ischemic stroke showed the protective effect of HLA-B-Bw4I alleles (B = − 3.649; p < 0.0001) and of interaction between KIR2DL2 and HLA-C1 (B = − 1.901; p = 0.004), whereas a detrimental effect was observed with regard to interaction between KIR2DS2 and HLAC2 (B = 2.687; p = 0.004) and between KIR2DL2 and HLA-C1_A (B = 1.847; p = 0.014) (see Table 4).