Multiple logistic regression analysis considering variables predictive of TOAST subtype of ischemic stroke showed a significant association between 2DL5A (B = 2.81; p = 0.03) and 3DL1 (B = 2.17; p = 0.02) KIR genes and cardioembolic stroke, whereas with regard to HLA alleles, only HLA-C1 allele (B = 2.36; p = 0.004) was significantly associated with cardioembolic stroke (see Tables 6 and 7). The gene discussed is KIR3DL1; the disease is cardioembolic stroke.