Our study showed that subjects with acute ischemic stroke in comparison with subjects without stroke were more likely to have a higher frequency of 2DL3, 2DL4, 2DL5B, 2DS2, 2DS4, and 3DP1 KIR genes and a significantly lower frequency of HLA-B-Bw4I allele. This evidence concerns the gene KIR3DL1 and Stroke.