A negative correlation was found between plasma levels of CRP and decreased connectivity between the ventral striatum and ventromedial prefrontal cortex (vmPFC) in medically stable MDD; connectivity between the striatum and vmPFC was associated with increased plasma levels of IL-6, IL-1β, and IL-1 receptor antagonists in medically stable MDD [98]. The gene discussed is IL6; the disease is major depressive disorder.