SLC25A13 and hepatocellular carcinoma: Moreover, preliminary quantification data by NMR in SLC25A13 silenced HCC cells indicate a decrease of glutamate levels compared to control cells (data not shown), suggesting that SLC25A13 gene silencing induces the conversion of glutamate in α-ketoglutarate via mitochondrial glutamate dehydrogenase (GDH) thus sustaining TCA cycle.