Additionally, a variety of murine models of intestinal inflammation, for example, induction of DSS (Dextran Sulphate Sodium)- and TNBS (2,4,6-trinitrobenzenesulfonic acid)-mediated colitis or genetic models of spontaneous inflammation, such as in the IL10-/- or Casp8ΔIEC mouse models, are characterized by increased TNFα levels in the intestinal mucosa [52,86,87,88,89,90]. This evidence concerns the gene TNF and colitis.