This effect is due to an increase in the number of natural killer cells (NK) and CD8 T cells (CD8) as well as their cytotoxicity, and to the abrogation of the immune-suppressive cells, the so-called myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg), in the tumor microenvironment [181]. The gene discussed is CD8A; the disease is neoplasm.