DES and cardiomyopathy, familial restrictive, 1: In familial RCM, sarcomeric and cytoskeletal gene mutations commonly reported in RCM include TNNI3, TNNT2, MYH7, DES, MYBPC3, LMNA, FLNC, and LAMP2. These mutations are involved in the progression of RCM due to impaired actin-myosin interactions and cardiac contractility [76,77,78].