NR4A1 and breast cancer: Interestingly, two recent independent studies provided preclinical evidence using MMTV-PyMT murine models of BC that mammary adipose tissue inflammation induced by diet enhanced the recruitment of macrophages, increased tumor vascular density [201] and hormone production in pre- and postmenopausal hormone receptor positive BRCA [202], suggesting a role for obesity in creating a microenvironment favorable for the progression of breast cancer.