Our data indicate that treatment with Api decreased A375 tumour cells reserve capacity considerably, which proves that it is more difficult for treated cancer cells to respond to stress than untreated cells or cells treated with DMSO (Reserve capacity for Api 30 μM → −9.8 ± 5.8 pmols/min vs. Control → −219.5 ± 24.5 pmols/min and for Api 60 μM → −84.6 ± 31.4 pmols/min vs. Control). The gene discussed is SERPINF2; the disease is neoplasm.