CASP3 and neoplasm: In the last decade, several studies have reported that Api can directly target mitochondria in tumour cell lines, revealing the activation of the mitochondrial apoptotic pathway; Api is associated with DNA fragmentation, production of reactive oxygen species, mitochondrial membrane depolarisation, release of cytochrome c and up-regulation of Bax, caspase 3, 9 and PARF [38,39,40].