Deng et al. [31,32] as well as Yin et al. [33] showed that increased ERα36 expression is important for the maintenance of the stem cell population in breast cancers, and Zhao indicated its role in tamoxifen resistance, which is possibly related to non-genomic signaling via the MAPK and Akt pathways [34]. This evidence concerns the gene AKT1 and breast carcinoma.