This topic is particularly important in children with regressive ASD apparently related to infections and high-fever episodes; (2) ex-vivo approaches in patient cells might be helpful to understand the effectiveness of RSV and synthetic PPAR activators in improving energy metabolism in ASD; (3) further studies using ASD models including a PPA rodent model could help to clarify whether activation of metabolic FAO using RSV and correction of related metabolic changes, such as abnormal acyl-carnitine profiles, run parallel to behavioral amelioration. This evidence concerns the gene PPARA and infection.