The importance of TRPM7 in cellular Mg2+ homeostasis has been investigated in several cell types, including leukocytes, platelets, vascular smooth muscle cells (VSMCs), cardiomyocytes, cardiac fibroblasts, osteoblasts, and tumor cells, in both physiological and pathological conditions [6,7,8,9,10,11,12,13]. The gene discussed is TRPM7; the disease is neoplasm.