IRPs are RNA binding proteins which, during cellular iron deficiency, either stabilise iron-related mRNAs (e.g., TFR1, for iron acquisition) by binding 3’UTR IREs, or mediate translational repression of mRNAs by binding 5’UTRs (e.g., FPN1, for iron export; FTH1, FTL encoding ferritin heavy and light chains respectively for iron storage) [6]. The gene discussed is SLC40A1; the disease is Iron deficiency anemia.