Moreover, missense mutations in the SNCA gene cause early-onset (A53T, E64K, A30P, G51D, and A53E) and late-onset (H50Q) forms of PD (Polymeropoulos et al., 1997, Krüger et al., 1998, Zarranz et al., 2004, Appel-Cresswell et al., 2013, Proukakis et al., 2013, Kiely et al., 2013, Pasanen et al., 2014, Martikainen et al., 2015). The gene discussed is SNCA; the disease is Parkinson disease.