SNCA and Parkinson disease: Since its inception (Outeiro and Lindquist, 2003), the yeast PD model with heterologous expression of α-synuclein has been successfully used not only to study molecular mechanisms of the PD but also for high-throughput drug and genetic screenings (Zabrocki et al., 2008, Menezes et al., 2015, Chen et al., 2017).