SNCA and Parkinson disease: In the human brain, an abnormal increase of α-synuclein expression levels may result in the aggregation of the protein into large complexes and amyloidogenic fibrils with the formation of intraneuronal proteinaceous inclusions known as Lewy bodies (Goedert et al., 2013), linked to the Parkinson’s disease (PD) pathogenesis (Goedert et al., 2017).