SNCA and Parkinson disease: The main limitation of the yeast PD model is that despite forming α-synuclein cytoplasmic inclusions (Outeiro and Lindquist, 2003, Cooper et al., 2006), which are also found in human neurons (Giasson et al., 1999, Cooper et al., 2006), these are not comprised of insoluble α-synuclein amyloid fibrils as found in Lewy bodies (Soper et al., 2008).