Rathmell’s group (Kishton et al., 2016) used a different model of T-ALL in which oncogenic NOTCH1 was expressed in murine hematopoietic stem cells that carried a floxed AMPK-α1 gene and Cre recombinase driven by a tamoxifen-inducible promoter. This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.