Median tumor-free survival was 94 days for PTEN-null mice with WT AMPK, and 75 days for those with either heterozygous or homozygous deletion of AMPK; the hazard ratios (Mantel-Haenszel), were 3.2 for heterozygous and 3.6 for homozygous AMPK deletion. This evidence concerns the gene PTEN and neoplasm.