We found an enrichment in highly scoring SSL pairs containing the tumour suppressors VHL and PTEN. SSL pairs with the highest consensus scores included SREBF1, a transcription factor that binds to sterol regulatory element-1 and VHL (confidence score 0.810) and PTEN and SFN, a gene associated with breast cancer (confidence score 0.808). The gene discussed is SREBF1; the disease is breast cancer.