In this cohort of 84 433 nationwide male veterans with T2D but without CLD who were insulin and thiazolidinedione naïve, we found that under no use of metformin, NHAA was associated with a 40% reduction in HCC incidence compared to NHW or Hispanic men should baseline clinical characteristics be calibrated between race/ethnic groups. This evidence concerns the gene INS and hepatocellular carcinoma.