At the time of identification, its relation to other gasdermins had not yet been established, and the gene was initially named Deafness Autosomal Dominant 5(DFNA5),11 only recently was it renamed GSDME. In addition to its role in hearing loss, GSDME is also a tumor suppressor gene capable of inducing programmed cell death as a result of a caspase‐3 cleavage.12 Given its role in cancer, epigenetic silencing through methylation has been shown in 52% and 65% of primary gastric tumors13 and colorectal adenocarcinomas14, 15 respectively. Here, GSDME is linked to cancer.