SIRT3 and neoplasm: However, SIRT3 regulates metabolic pathways differently in tissues producing and utilizing fuel.36 Recent studies have shown that by targeting a range of crucial regulators and their relevant pathways in tumors, SIRT3 may perform the role of either tumor suppressor or oncogene by affecting cell growth.37 Accordingly, SIRT3 influences the biological behaviors of various tumors through different metabolic regulation patterns.