PDH plays a crucial regulatory role by tuning glycolytic metabolism in cancer cells.50, 51 Enhanced glycolysis inhibited pyruvate dehydrogenase flow, and downregulated TCA cycle labeling, consistent with the Warburg effect.52 Furthermore, several studies reported that SIRT3 expression may be correlated with hexokinase‐1 (HK1) and hexokinase‐2 (HK2) expression in the regulation of glucose metabolism in ovarian cancer cells. The gene discussed is SIRT3; the disease is cancer.