HIF1α is a transcription factor that regulates the expression of glycolytic‐related genes.18 SIRT3 also inhibits tumor progression by targeting the manganese superoxide dismutase (MnSOD), reducing the production of reactive oxygen species (ROS) and genomic instability.19 Therefore, the stability of HIF1α is regulated through SIRT3‐mediated mitochondrial metabolism.18, 20 In previous studies,21, 22, 23 HIF1α increased pyruvate dehydrogenase kinase 1 (PDK1), which limited the amount of pyruvate entering the citric acid cycle, leading to a reduction in mitochondrial oxygen consumption. Here, SOD2 is linked to neoplasm.