SIRT3 and neoplasm: Previous studies suggested that SIRT3 might play an important role in inhibiting cancer proliferation and progression.20, 33, 34 However, in other tumors, studies have shown that SIRT3 may be a cancer‐promoting gene.14, 35 These phenomena may be because SIRT3, a deacetylase, has multiple substrates, which allows it to promote tumor progression in one circumstance, and inhibit tumor progression under other circumstances.