JAG1 and ovarian cancer: This is consistent with the finding that Jagged1 knockdown cells retained an epithelial morphology and failed to disassemble E‐cadherin adherens junctions and cortical actin bundles.40 Furthermore, Choi and Steg et al also demonstrated that Jagged1 is the main Notch ligand in ovarian cancer and silencing it reduced viability and sensitized them to taxane treatment both in vitro and in vivo, where it drastically reduced tumour growth.