GPX4 and acute kidney injury: Notably, GPX4, which is unique among GPXs isoforms, is the only enzyme that regulates the lipid ROS balance during ferroptosis.20 Additionally, GPX4 enzymatic activity depends on the cystine/glutamate antiporter system xc‐.21 In summary, ferroptosis is involved in AKI, and suppression of ferroptosis may provide new therapeutic strategies for AKI.