We have found that the growth of A549‐LKB1 was compromised and the cells failed to develop tumour in nude mice.26 To assess if the inhibitory effect of LKB1 on the cancer cell growth is mediated by AMPK, we deleted β1 and β2 subunits on the context of A549‐LKB1 (Figures 2C and 4A). This evidence concerns the gene PRKAA1 and cancer.