PDZK1 and hyperuricemia: The present study also demonstrated that SUA is regulated by multiple “transport”-related genes, that is, not only urate transporter genes but also non-transporter genes such as PDZK1 and HNF4A. Our findings thus provide important insight into SUA regulation and the pathogenesis of hyperuricemia and gout, and they provide a potential basis for the development of new treatments for these diseases.