For instance, depletion of dual leucine zipper kinase, a MAPKKK that preferentially activates Jnk but may also activate Erk and p38 MAPKs, increases the expression of guidance receptors Epha7, Nrp1, Plxna4, and Unc5a, and downregulates the expression of the ligand Sema6b in cultured mouse Neuro-2a neuroblastoma cells (Blondeau et al., 2016). The gene discussed is MAPK8; the disease is neuroblastoma.