Ionomycin (a calcium ionophore and pore-forming molecule), MSU crystals (which activate leukocytes via Toll-like receptors and the inflammasome driving gout), PMA (which activates protein kinase C and thus NF-κB), and C. albicans are diverse and common stimulants of NETosis with innumerable connections to autoimmune disease. This evidence concerns the gene NFKB1 and autoimmune disease.