Table 4 shows that the GPR54 gene novel polymorphism Chr19: 918735 was associated with an increased PCOS risk: in the recessive model, genotype GG (OR=2.53, 95% CI: 0.97-6.57, p=0.043). Moreover, the five gene models also showed no association between genotypes of Kiss1 SNPs and PCOS risk (Table 5). In addition, there was no significant association of PCOS with the haplotypes of GPR54 (rs10407968/ rs1250729403/ rs350131/ Chr19:918686/ Chr19:918735) and Kiss1 (rs5780218/ rs4889) (Tables 6 and 7). Here, KISS1 is linked to polycystic ovary syndrome.