They also found that high levels of EBF2 were associated with high OPG protein levels in osteosarcoma samples and knockdown of EBF2 result in stunted abrogation of OPG levels and increased sensitivity to tumor necrosis factor–related apoptosis-inducing ligand (TRAIL)–induced apoptosis [19]. The gene discussed is TNFSF10; the disease is osteosarcoma.