BAX and cancer: Upregulation and activation of Bax have been determined in many apoptotic models, such as androgen stimulated osteoblast and osteocyte apoptosis [11], BMP-2 induced osteoblast apoptosis [12], recombinant IL-1β induced cell cycle arrest, and apoptosis in neural precursor cells [13] and in cancer cell apoptosis [14, 15].