Network analysis on the cancer genome atlas (TCGA) breast cancer dataset revealed interaction between CXCL12 and CXCR7 (ACKR3), and a number of G-protein family members (GNG5, GNB4, GNB2, GNG12, GNG7, GNGT1, and GNAI3, Fig. 6a). This evidence concerns the gene GNB4 and breast carcinoma.