Neighborhood CRC_M7.n8, lacking enrichment of established ontology terms, included the hub genes FCGBP and ST6GALNAC1 as well as SPINK4 and MUC2, that are characteristic goblet cell markers linked to CMS3 CRC.6,24 The closely linked neighborhood CRC_M7.n1 included hub genes REG4, AGR2 and AGR3 (Fig. 4b, online). This evidence concerns the gene AGR3 and colorectal carcinoma.