RNF213 and multiminicore myopathy: The major findings are as follows: (a) the ICASO with the RNF213 c.14576G>A variant possessed less symptomatic patients and milder presentation compared with wild-type genotype; (b) collateral vessels were more common in ICASO with RNF213 variant; (c) ICASO with the RNF213 variant was characterized by features of both HR-MMD and HR-ICAD.