NUMB and Hepatic fibrosis: In support of this hypothesis, a zebrafish hepatic fibrosis model found that antagonism of Notch signaling promoted LPC-to-hepatocyte differentiation [6], and a mouse model of steatohepatitis found that macrophage expression of Jagged1 promoted differentiation of LPCs into BECs, while expression of NUMB that impairs Notch signaling promoted differentiation of LPCs into hepatocytes [44].