Administration of ADR significantly (P <0.05) increased levels of GRP-78, p-IRE1α, and p-JNK compared to the CTR group whereas levels of GRP-78, p-IRE1α, and p-JNK levels in ADR + DA 100 and AD + DA 200 groups were significantly (P <0.05) lower than those in the ADR group. Here, MAPK8 is linked to Alzheimer disease.