An earlier GSK2256098 monotherapy study similarly found that patients with Merlin-negative mesothelioma had longer PFS than those with Merlin-positive mesothelioma.7 The prognostic significance of Merlin status has been recently reported by Meerang.18 Meerang et al reported in two independent cohorts of mesothelioma patients that low tumour Merlin expression is associated with a poorer freedom from recurrence and poorer overall survival than in mesothelioma patients with higher Merlin expression. This evidence concerns the gene NF2 and mesothelioma.