IFNG and colitis: Altogether, the absence of IL-10 production by both RORγt+/− Treg and TH17 cells associated with the increase production of IFN-γ by TH17 cells in MafΔTcells mice most probably lead to colitis onset.IL-10 production by Treg is essential to maintain homeostasis at environmental surfaces by directly suppressing pathogenic TH17 cells and TH17/TH1 cells25.